CellGenix® rh OSM

Preclinical grade

CellGenix Recombinant Human OSM promotes the differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) derived hepatoblasts into hepatocytes. It is produced in our dedicated animal-free facility ensuring maximum safety for optimal use in ATMP manufacturing.

General Information

Oncostatin M (OSM) is a cytokine belonging to the interleukin-6 (IL-6) subfamily and it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. It is primarily produced by T cells and monocytes. OSM plays an important role in liver development, hematopoiesis, and inflammation, and also has been shown to be associated with bone formation and resorption.

Preclinical Grade

The final manufacturing steps and quality control of all our preclinical grade products are performed in a GMP facility ensuring a consistent high quality.

name
CellGenix® Recombinant Human Oncostatin M
Source
E. coli
Formulation
Lyophilized
ANIMAL-DERIVED COMPONENT-FREE
CellGenix® Preclinical rh OSM
amount
Order Number
50  µg
1423-050

CellGenix® rh OSM

Features

  • Produced in our dedicated animal-free facility
  • High purity, activity and product stability

Applications

  • Differentiation of ESCs and iPSCs into hepatocytes

Technical Details

Source
Expressed in E. coli
Description

Human OSM, accession #P13725, Ala26-Arg221

Formulation

Lyophilized from a 0.2 µm-filtered solution in PBS

Final manufacturing steps and Quality Control (QC) are performed in a GMP facility.

 Preclinical
Molecular weight22.1 kDa
Purity≥ 95% as determined by SDS-PAGE
Activity> 40 x 106 IU/mg, calibrated against NIBSC #93/564 Cell proliferation assay using a human factor dependent cell line, TF-1 
Endotoxin level< 1000 EU/mg
Intended useIntended for preclinical ex vivo use. Not intended for therapeutic use.

 

Handling Instructions

Reconstitution

Recommended in sterile water to a final concentration of 250 µg/ml.

Shipment

Ambient temperature. Please refer to Technote to learn more about our shipment validation procedure.

Expiry

3 years from date of shipment.

Storage & Stability

Store lyophilized cytokine at -20°C to -80°C.

Avoid repeated freeze/thaw cycles.

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